The Churches of San Clemente and Santi Quattro Coronati are wall-to-wall Medieval art, both frescoes and marble intarsia! In fact, Maria Macellaria and her consort commissioned several frescoes for the Church of San Clemente in the year 1000. Three of these frescoes were dedicated to the eponymous saint, and one was in honor of then-popular Saint Alexis. The frescoes are still visible and the anonymous artist(s) caught the Christian community’s attention by using humorous cartoon-style vignettes to illustrate miracles and human foibles. After discussing these scenes, their content, and their style, we focus on the apse mosaics in the upper church.